The mature market for enterprise business applications is buckling under its own complexity, failing to deliver the agility and value that modern businesses demand. AI will not incrementally improve these applications; it will dismantle and reinvent them into an “agentic business fabric.” This new paradigm automates and orchestrates data, workflows, and human expertise through a composable, intelligent mesh, rendering traditional application silos obsolete. This report provides CIOs and enterprise leaders with a strategic playbook to navigate this transformation, outlining the architectural layers of the future and the concrete actions required to prepare for an agent-first world.